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张保军  
研究领域(方向)

研究免疫细胞发育分化调控机制,筛选和研发抗肿瘤、抗感染及自身免疫性疾病的治疗靶点与药物,主要包括:

1)解析αβTγδTNKT细胞在胸腺内的早期发育及在外周长期维持的分子机制,阐明各种T细胞亚群如何维持机体完整的免疫系统;

2)探讨调控效应性与记忆性T细胞分化、维持的分子机制及其在抗感染、肿瘤等疾病中的应用;

3)研究调控效应性T细胞和调节性T细胞参与自身免疫性疾病发生的机制,寻找治疗自身免疫性疾病的靶点。

个人及工作简历

教授、博导、云鼎国际4118登录基础医学院院长

中国西部科技创新港转化医学研究院院长

国家级青年人才,陕西省领军人才

陕西省科技创新团队负责人

陕西省高校青年创新团队负责人

西安市免疫相关疾病基础与转化重点实验室主任

云鼎国际4118登录青年拔尖人才”A

科研项目

科技部重点研发计划课题1

基金委国际(地区)合作重点项目1

国家自然基金面上项目2

学术及科研成果、专利、论文

主要业绩

ImmunityJ Clin InvestSci AdvPNASJ Immunother CancerSignal Transduct Target TherJ Adv ResElifePlos GeneticsJ Immunol等杂志上公开发表SCI论文40余篇,共被引用1000余次;担任中国免疫学会理事陕西省抗癌协会、细胞生物学学会副理事长,器官与系统整合教材-副主编。Front Cell Dev BiolBMC ImmunolJ Cell Mol Med杂志Associated Editor担任Int ImmunopharmacolFront Immunol杂志的编委。

代表性论文

1. Wang, X.; Sun, L.; Yang, B.; Li, W.; Zhang, C.; Yang, X.; Sun, Y.; Shen, X.; Gao, Y.; Ju, B.; Gao, Y.; Liu, D.; Song, J.; Su, Y.; Jiao, A.; Liu, H.; Zhang, L.; He, L.; Lei, L.; Chen, W.; Zhang, B., Zfp335 establishes eTreg lineage and neonatal immune tolerance by targeting Hadha-mediated fatty acid oxidation. J Clin Invest 2023 (In Press)

2. Jiao, A.; Sun, C.; Wang, X.; Lei, L.; Liu, H.; Li, W.; Yang, X.; Zheng, H.; Ding, R.; Zhu, K.; Su, Y.; Zhang, C.; Zhang, L.; Zhang, B., DExD/H-box helicase 9 intrinsically controls CD8(+) T cell-mediated antiviral response through noncanonical mechanisms. Sci Adv 2022, 8 (6), eabk2691.

3. Zhang, C.; Lei, L.; Yang, X.; Ma, K.; Zheng, H.; Su, Y.; Jiao, A.; Wang, X.; Liu, H.; Zou, Y.; Shi, L.; Zhou, X.; Sun, C.; Hou, Y.; Xiao, Z.; Zhang, L.; Zhang, B., Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice. J Immunother Cancer 2021, 9 (10).

4. Jiao, A.; Zhang, C.; Wang, X.; Sun, L.; Liu, H.; Su, Y.; Lei, L.; Li, W.; Ding, R.; Ding, C.; Dou, M.; Tian, P.; Sun, C.; Yang, X.; Zhang, L.; Zhang, B., Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species. J Adv Res 2023.

5. Sun, L.; Su, Y.; Jiao, A.; Wang, X.; Zhang, B., T cells in health and disease. Signal Transduct Target Ther 2023, 8 (1), 235.

6. Wang, X.; Jiao, A.; Sun, L.; Li, W.; Yang, B.; Su, Y.; Ding, R.; Zhang, C.; Liu, H.; Yang, X.; Sun, C.; Zhang, B., Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms. Elife 2022, 11.

7. Liu, H.; Wang, X.; Ding, R.; Jiao, A.; Zheng, H.; Zhang, C.; Feng, Z.; Su, Y.; Yang, X.; Lei, L.; Sun, L.; Zhang, L.; Sun, C.; Zhang, B., The Transcription Factor Zfp335 Promotes Differentiation and Persistence of Memory CD8(+) T Cells by Regulating TCF-1. J Immunol 2022, 209 (5), 886-895.

8. Jiao, A.; Liu, H.; Ding, R.; Zheng, H.; Zhang, C.; Feng, Z.; Lei, L.; Wang, X.; Su, Y.; Yang, X.; Sun, C.; Zhang, L.; Bai, L.; Sun, L.; Zhang, B., Med1 Controls Effector CD8(+) T Cell Differentiation and Survival through C/EBPβ-Mediated Transcriptional Control of T-bet. J Immunol 2022, 209 (5), 855-863.

9. Zhang, B.; Liu, S. Q.; Li, C.; Lykken, E.; Jiang, S.; Wong, E.; Gong, Z.; Tao, Z.; Zhu, B.; Wan, Y.; Li, Q. J., MicroRNA-23a Curbs Necrosis during Early T Cell Activation by Enforcing Intracellular Reactive Oxygen Species Equilibrium. Immunity 2016, 44 (3), 568-581.

10. Zhang, B.; Jia, Q.; Bock, C.; Chen, G.; Yu, H.; Ni, Q.; Wan, Y.; Li, Q.; Zhuang, Y., Glimpse of natural selection of long-lived T-cell clones in healthy life. Proc Natl Acad Sci U S A 2016, 113 (35), 9858-63.

11. Zhang, B.; Jiao, A.; Dai, M.; Wiest, D. L.; Zhuang, Y., Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity. J Immunol 2018, 201 (5), 1452-1459.

12. Zhang, B.; Wu, J.; Jiao, Y.; Bock, C.; Dai, M.; Chen, B.; Chao, N.; Zhang, W.; Zhuang, Y., Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol 2015, 195 (9), 4282-91.

13. Zhang, B.; Lin, Y. Y.; Dai, M.; Zhuang, Y., Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells. J Immunol 2014, 192 (3), 1055-1063.

14. Liu, J.; Zhang, H.; Su, Y.; Zhang, B., Application and prospect of targeting innate immune sensors in the treatment of autoimmune diseases. Cell Biosci 2022, 12 (1), 68.

15. Yang, X.; Wang, X.; Lei, L.; Su, Y.; Zou, Y.; Liu, H.; Jiao, A.; Zhang, C.; Liu, J.; Li, W.; Ding, R.; Zhou, X.; Shi, L.; Zhang, D.; Sun, C.; Zhang, B., Arid1a promotes thymocyte development through β-selection-dependent and β-selection-independent mechanisms. Immunology 2022, 165 (4), 402-413.

联系方式
电子邮箱:bj.zhang@mail.xjtu.edu.cn
联系电话:029-82656681、18991906676
联系地址:雁塔西路76号微免楼
更新日期:2023-08-25